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SCI封面设计

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STTT 期刊封面设计

STTT 期刊封面设计

封面巧妙借用中国川剧“变脸”意象表现SARS-CoV-2不断发生的抗原变异。镜中的脸谱象征病毒的抗原特征，不断描绘和变化的面孔对应刺突蛋白突变形成的不同变异株，而脸谱周围类似病毒突起的结构进一步强化SARS-CoV-2主题。原本能够被抗体识别的“面孔”随着突变不断改变，使免疫系统越来越难以辨认，从而形象表现Omicron等变异株的抗原漂移与免疫逃逸。

Nature Protocols 期刊封面设计

Nature Protocols 期刊封面设计

This image illustrates a bioswitchable delivery system designed to achieve controlled loading and release of miRNA regulators. A ribonuclease H-sensitive sequence functions as the bioswitchable apparatus, enabling release of the miRNA regulator upon ribonuclease H binding (green). See Li et al.

Nature Methods 期刊封面设计

Nature Methods 期刊封面设计

Advanced nanopore-based peptide sequencing
Peptide sequencing by nanopore: a crow drops grapes into a pitcher with a narrow neck, representing the cleavage of a peptide into amino acids and their subsequent detection by a modified nanopore.

Nature Neuroscience 期刊封面设计

Nature Neuroscience 期刊封面设计

EEG wake-to-sleep transition
The artwork portrays the brain’s descent into sleep as a falling trajectory from a wakefulness attractor into a sleep attractor, as symbolized by an hourglass. The falling sand is represented by the brain’s electroencephalogram (EEG) signals of wakefulness and sleep, while the neck of the hourglass represents a kinetic energy barrier. Li et al. used this conceptual framework to demonstrate that the human brain’s transition into sleep shows an abrupt, falling-like bifurcation trajectory, with a momentary tipping point that can be accurately predicted in real time.

Nature biontech 期刊封面设计

Nature biontech 期刊封面设计

The Sequencing Quality Control 2 (SEQC2/MAQC-IV) project provides resources to aid sequencing reproducibility and highlights factors that can guide platform and software choice.

STTT 期刊封面设计

STTT 期刊封面设计

封面以夜色中的花朵、蝴蝶与DNA双螺旋构建富有寓言感的免疫微环境。盛开的花朵象征肿瘤细胞及其表面抗原，蓝色蝴蝶则寓意CAR-T细胞在肿瘤间进行识别与攻击；蝴蝶与花朵之间不断发生的接触，隐喻“trogocytosis（啃噬作用）”导致CAR分子在细胞之间异常转移。随着CAR被肿瘤细胞夺取，CAR-T识别能力下降、肿瘤抗原被遮蔽，从而形成免疫逃逸。整体以柔和的自然意象表现CAR-T治疗过程中复杂的细胞博弈。

STTT 期刊封面设计

STTT 期刊封面设计

封面以“鲲鹏/飞鲸冲破云海”的东方幻想场景表现成人新生神经元在癫痫神经环路中的异常重塑。画面中散布的神经元形态象征不同阶段生成的齿状回颗粒细胞，彼此延伸连接的结构寓意异常兴奋性神经环路；巨大的飞行生物穿越云层，则强化了神经网络被重新组织并持续推动癫痫活动的动态感。整体通过“新生—连接—异常放大”的视觉叙事，表现关键期成人新生神经元维持海马癫痫发作的研究机制。

STTT 期刊封面设计

STTT 期刊封面设计

封面以大脑和神经系统肿瘤微环境为核心场景，深色肿瘤团块象征弥漫性中线胶质瘤，向上喷涌、扩散的发光颗粒则寓意表观遗传药物诱导的分子变化及免疫反应被重新激活。大脑与下方病灶通过连续的信号流相连接，表现表观遗传调控、肿瘤微环境和免疫系统之间的相互作用，整体传达“通过表观遗传干预唤醒抗肿瘤免疫，从而抑制DMG”的研究主题。

Advanced Science 期刊封面设计

Advanced Science 期刊封面设计

The cover illustration features a tetrahedral-framed spacecraft situated on a dune, which continues to interact with its base through its vertex components following disintegration. In article number 2411210 by Taoran Tian, Yunfeng Lin, and co-workers, a protective strategy against acute liver and kidney injury has been developed based on an enzyme-responsive nanostructure.

ACS Nano 期刊封面设计

ACS Nano 期刊封面设计

The DNA nanoshot based on tetrahedral framework nucleic acids was encapsulated within pH-responsive enteric capsules. This enabled the oral delivery of siRNA targeting galcetin-3 and showed excellent gastric stability and intestinal penetration to ameliorate liver fibrosis. This mode provides a potential strategy with oral siRNA delivery for chronic diseases.

ACS Nano 期刊封面设计

ACS Nano 期刊封面设计

A polyphenol–ionic liquid supramolecular system assembles therapeutic macromolecules into stable nanostructures capable of penetrating oral mucosal barriers. The platform enhances molecular stabilization, coordinated immunomodulation, and pro-osteogenic activity, offering a non-invasive strategy for treating deep-seated inflammatory periodontal lesions.

Advanced Materials 期刊封面设计

Advanced Materials 期刊封面设计

Materials Research Thrives at Sichuan University
To commemorate the 125th anniversary of the founding of Sichuan University, this special issue presents an overview of the latest progress of materials research at this university. Topics include vaccine-delivery systems, tissue-engineering materials, intelligent materials, commodity polymeric materials, biomimetic materials, advanced energy materials, flame-retardant materials, separation materials, framework nucleic-acid-based nanomaterials, and quantum dots and magic-size clusters.

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